Sb. Vaisanen et al., Regular exercise, plasminogen activator inhibitor-1 (PAI-I) activity and the 4G/5G promoter polymorphism in the PAI-1 gene, THROMB HAEM, 82(3), 1999, pp. 1117-1120
The aim of this controlled randomised clinical trial was to investigate the
effects of regular low to moderate intensity physical activity on plasmino
gen activator inhibitor-1 (PAI-1) activity during three years while taking
into account the 4G/5G polymorphism in the promoter of the PAI-1 gene. Male
subjects (age 52-62 years, n = 132) were randomised into an exercise or a
(non-intervention) reference group. Aerobic threshold increased by 8.8% (p
= 0.025) in the exercise group, and decreased by 1.1% in the non-interventi
on group, while PAI-1 activity did not change significantly in either study
group. However! homo zygotes for the 4G allele in the exercise group showe
d a 36% reduction in PAI-1 (p = 0.025). In conclusion, although regular mod
erate physical activity did not decrease PAI-1 activity in the whole group,
regular exercise ma) be effective for controlling elevated PAI-1 level in
subjects homozygous for the 4G allele.