Early relapse of psychotic symptoms after an initial response to olanzapine

This is a report of two cases with schizophrenia in which a good response t o olanzapine in an acute 6-week treatment phase was obtained, followed by e arly relapse without any clear contributing factors. Referring to a few oth er case reports of early relapse after an initial response to atypical anti psychotics other than olanzapine, the possibility is discussed that rapid d isplacement of these drugs due to loose binding could play a role in early relapse.