This is a report of two cases with schizophrenia in which a good response t
o olanzapine in an acute 6-week treatment phase was obtained, followed by e
arly relapse without any clear contributing factors. Referring to a few oth
er case reports of early relapse after an initial response to atypical anti
psychotics other than olanzapine, the possibility is discussed that rapid d
isplacement of these drugs due to loose binding could play a role in early
relapse.