Seminal plasma anaphylaxis: successful pregnancy after intravaginal desensitization and immunodetection of allergens

For seminal plasma-allergic patients to achieve pregnancy, immunotherapy or artificial insemination is recommended. However, these modalities require complicated procedures. We recently treated a patient with human seminal pl asma anaphylaxis who was successfully desensitized after intravaginal rush desensitization and became spontaneously pregnant. She had a healthy full-t erm infant. With immunoblotting, we identified multiple allergens in her hu sband's seminal plasma, with molecular masses such as 100, 75, 65, 50, 40, 38, 33, 20, and 18 kDa, and the pattern of immunoblotting did not change af ter desensitization. We found not only specific antibodies to the seminal p lasma of the patient's partner, but also common antibodies to both the part ner's and the control specimen. Our results suggest that intravaginal desen sitization might be an effective and convenient initial approach for patien ts who want to achieve pregnancy, and also confirm the presence of both the specific and shared common allergens in the seminal plasmas of the patient 's partner and the control subject.