Glutathione S-transferase M1 genotypes and the risk of squamous carcinoma of the cervix: A population-based case-control study

The authors determined the GSTM1 genotype of 190 Caucasian women with invas ive squamous cell cervical cancer in western Washington State between Janua ry 1986 and June 1994 and of 206 controls. It was found that 53% of cases a nd 57% of controls had the GSTM1 null genotype. The age-adjusted odds ratio associated with GSTM1 null genotype was 0.8 (95% confidence interval 0.6, 1.3). The lack of association between cervical cancer risk and GSTMI genoty pe was true both for smokers and nonsmokers of cigarettes and for heavy and light smokers. These data suggest that women with the GSTMI null genotype are not at increased risk of cervical cancer.