A. Melian et al., CD1 expression in human atherosclerosis - A potential mechanism for T cellactivation by foam cells, AM J PATH, 155(3), 1999, pp. 775-786
Citations number
68
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research Diagnosis & Treatment
Atherosclerotic plaques are chronic inflammatory lesions composed of dysfun
ctional endothelium, smooth muscle cells, lipid-laden macrophages, and T ly
mphocytes. This study analyzed atherosclerotic tissue specimens for express
ion of CD1 molecules, a family of cell surface proteins that present lipid
antigens to T cells, and examined the possibility that CD1+ lipid-laden mac
rophages might present antigen to T cells. Immunohistochemical studies usin
g a panel of specific monoclonal antibodies demonstrated expression of each
of the four previously characterized human CD1 proteins (CD1a, -b, -c, and
-d) in atherosclerotic plaques, Expression of CD1 was not observed in norm
al arterial specimens and appeared to be restricted to the CD68+ lipid-lade
n foam cells of atherosclerotic lesions. CD1 molecules colocalized in areas
of the arterial wall that also contained abundant T lymphocytes, suggestin
g potential interactions between CD1+ cells and plaque-infiltrating lymphoc
ytes in situ. Using CD1-expressing foam cells derived from macrophages in v
itro,we demonstrated the ability of such cells to present lipid antigens to
CD1 restricted T cells, Given the abundant T cells, CD1+ macrophages, and
lipid accumulation in atherosclerotic plaques, we propose a potential role
for lipid antigen presentation by CD1 proteins in the generation of the inf
lammatory component of these lesions.