Le. Vanatta et De. Coleman, Retention-time optimization in ion chromatography: An application of experimental design in the semiconductor industry, AM LABORAT, 31(18), 1999, pp. 32
Several researchers have utilized DOE (design of experiments) to optimize c
hromatographic separations. However, these efforts have involved detailed m
athematical analysis; of the data. The work presented in this paper will sh
ow how simple design methodology can quickly optimize retention times.