AL amyloid arthropathy. Review of the literature.

This review is aimed at defining the frequency, the clinical, biological an d radiological presentation and the therapeutic possibilities for AL amyloi d arthropathies. The frequency of AL amyloid arthropathy is estimated to be between 2 and 5% , There is usually a bilaterally progressive symmetrical arthritis of multi ple joints (predominantly in the upper limb joints) with a chronic evolutio n. Neurologic or cutaneous symptoms are common. The analysis of synovial fl uid sediments is a key test for the diagnosis of amyloid arthropathy, Patie nts with amyloid arthropathy must be screened for monoclonal gammapathies. The synovectomy is the best symptomatic treatment. A better knowledge of the pathogenesis of amyloid deposits should permit to improve therapeutical strategies.