Sa. Tasker et al., Efficacy of influenza vaccination in HIV-infected persons - A randomized, double-blind, placebo-controlled trial, ANN INT MED, 131(6), 1999, pp. 430-433
Citations number
20
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Background: Although influenza vaccination is recommended in persons infect
ed with HIV-1, its efficacy is unknown.
Objective: To assess the immunogenicity, efficacy, and risks associated wit
h influenza vaccination in persons infected with HIV-1.
Design: Randomized, double-blind, placebo-controlled trial.
Setting: Outpatient military clinic.
Patients: 102 patients with HIV-1 infection.
Intervention: Influenza vaccine (n = 55) or saline pla cebo (n = 47).
Measurements: Influenza antibody titers, CD4(+) cell counts, and plasma HIV
-1 RNA levels at baseline, 1 month after immunization, and 3 months after i
mmunization; viral cultures from persons presenting with respiratory illnes
s; and respiratory symptom interview.
Results: Twenty-three placebo recipients (49%) and 16 vaccine recipients (2
9%) reported respiratory symptoms (P = 0.04). Ten placebo recipients but no
vaccine recipients had laboratory-confirmed symptomatic influenza (P < 0.0
01) (protective efficacy, 100% [95% CI, 73% to 100%]). No effect on plasma
HIV-1 RNA levels or CD4+ cell counts was noted.
Conclusion: Influenza vaccination is highly effective in HIV-l-infected per
sons and does not seem to be associated with substantial changes in viral l
oad or CD4 cell count.