Comparison of pentastarch and Hartmann's solution for volume preloading inspinal anaesthesia for elective Caesarean section

We studied 160 patients undergoing elective Caesarean section under spinal anaesthesia who received a preloading volume of 15 ml kg(-1) of 10% pentast arch in 0.9% saline, or Hartmann's solution, in a prospective, randomized, double-blind study. We compared the incidence of spinal-induced hypotension in each group. Hypotension was defined as a decrease in systolic arterial pressure to less than 70% of baseline values or less than or equal to 90 mm Hg, whichever was the greater. The groups were comparable in physical char acteristics and there was no serious morbidity. Fetal outcome was similar i n both groups. Significantly more patients in the Hartmann's group (n=38, 4 7.5%) developed hypotension than in the pentastarch group (n=10, 12.5%) (P< 0.0001). Linear regression analysis showed that the only significant variab le was type of fluid used. Blood glucose concentrations were not related to the presence of hypotension. We conclude that starches may be suitable for preloading in Caesarean section under spinal anaesthesia and provide an al ternative to the aggressive use of vasoconstrictors.