Desmopressin enhances the binding of plasma von Willebrand factor to collagen in plasmas from normal dogs and dogs with Type I von Willebrand's disease

Authors
Citation
Ib. Johnstone, Desmopressin enhances the binding of plasma von Willebrand factor to collagen in plasmas from normal dogs and dogs with Type I von Willebrand's disease, CAN VET J, 40(9), 1999, pp. 645-648
Citations number
19
Categorie Soggetti
Veterinary Medicine/Animal Health
Journal title
CANADIAN VETERINARY JOURNAL-REVUE VETERINAIRE CANADIENNE
ISSN journal
00085286 → ACNP
Volume
40
Issue
9
Year of publication
1999
Pages
645 - 648
Database
ISI
SICI code
0008-5286(199909)40:9<645:DETBOP>2.0.ZU;2-D
Abstract
A new in vitro von Willebrand factor-collagen binding activity (vWF:CBA) as say was used to assess qualitative changes in vWF in normal dogs and dogs w ith Type I von Willebrand's disease (vWD) following treatment with desmopre ssin acetate (DDAVP). Although DDAVP induced increases in VWF antigen conce ntrations at 1 hour postinfusion in both normal and vWD dogs (57% and 60% i ncreases, respectively), there were disproportionately greater increases in vWF:CBA (96% and 103% increases). These results support the hypothesis tha t the enhanced hemostatic activity induced by DDAVP is, at least in part, d ue to the selective release of more functionally active vWF multimers. The assay, as described, provides a convenient means of simultaneously assessin g vWF quantity and function before and after DDAVP administration.