Triplet repeat disorders: discussion of molecular mechanisms

Comparison of the growing number of disorders known to be associated with t riplet repeat expansions reveals both common features and a diversity of mo lecular pathways. Despite significant progress towards the characterization of proteins coded by the mutant genes, the complex nature of these disorde rs requires identification of all molecular components of the triplet repea t pathways. In this brief review we will discuss recent progress in determi ning the molecular mechanisms of disorders with unstable trinucleotide muta tions.