J. Klose et al., 2-Propanephosphonic acid anhydride (T3P)-mediated segment coupling and head-to-tail cyclization of sterically hindered peptides, CHEM COMMUN, (18), 1999, pp. 1847-1848
In the course of comparing the effectiveness of an HOAt-derived coupling re
agent (HAPyU) and a phosphonic acid-based condensation agent (T3P) by cycli
zation of model sequences, we found that T3P was a superior reagent with re
gard to conversion of the linear peptide into the stereochemically intact c
yclic monomer when sterically hindered amino acids are found at the cycliza
tion site.