Signalling to actin: the Cdc42-N-WASP-Arp2/3 connection

Authors
Carlier, MF Ducruix, A Pantaloni, D
Citation
Mf. Carlier et al., Signalling to actin: the Cdc42-N-WASP-Arp2/3 connection, CHEM BIOL, 6(9), 1999, pp. R235-R240
Citations number
28
Categorie Soggetti
Biochemistry & Biophysics
Journal title
CHEMISTRY & BIOLOGY
ISSN journal
10745521 → ACNP
Volume
6
Issue
9
Year of publication
1999
Pages
R235 - R240
Database
ISI
SICI code
1074-5521(199909)6:9<R235:STATCC>2.0.ZU;2-2
Abstract
The molecular link between the signalling pathway regulating the formation of filopodia and the initiation of local actin polymerization has been eluc idated: N-WASP, a close homologue of WASP, which is the product of the gene responsible for the Wiskott-Aldrich syndrome, mediates a direct connection between the small G-protein Cdc42 and the Arp2/3 complex.