Citation
La. Amos et J. Lowe, How Taxol (R) stabilises microtubule structure, CHEM BIOL, 6(3), 1999, pp. R65-R69
Citations number
21
Categorie Soggetti
Biochemistry & Biophysics
Journal title
CHEMISTRY & BIOLOGY
ISSN journal
10745521
→ ACNP
Volume
6
Issue
3
Year of publication
1999
Pages
R65 - R69
Database
ISI
SICI code
1074-5521(199903)6:3<R65:HT(SMS>2.0.ZU;2-I
Abstract
The structure of tubulin shows paclitaxel (Taxol (R)) binding to a pocket i
n beta tubulin on the microtubule's inner surface, which counteracts the ef
fects of GTP hydrolysis occurring on the other side of the monomer.