A new method with general diagnostic utility for the calculation of immunoglobulin G avidity

The reference method for immunoglobulin G (IgG) avidity determination inclu des reagent-consuming serum titration. Aiming at better IgG avidity diagnos tics, we applied a logistic model for the reproduction of antibody titratio n curves. This method was tested with well-characterized serum panels for c ytomegalovirus, EpsteinBarr virus, rubella virus, parvovirus B19, and Toxop lasma gondii. This approach for IgG avidity calculation is generally applic able and attains the diagnostic performance of the reference method while b eing less laborious and twice as cost-effective.