Basic symptoms and P300 abnormalities in young schizophrenic patients

Among the reasons for the relatively limited number of investigations of se lf-knowledge phenomena should be included, in addition to theoretical motiv es, the difficulties regarding the use of instruments available for this ki nd of approach and their content validity. This study investigates the rela tionship between subjective and objective deficits in schizophrenia, taking into account subjective experiences of cognitive impairment, clinical symp toms, and cognitive evoked potentials (P300 component). A group of 36 young schizophrenic patients (29 on neuroleptic treatment and seven drug-naive) were considered, together with a comparison group of 36 healthy subjects. A uditory event-correlated potentials (ERPs) were obtained using a simple "od dball" paradigm. Clinical symptoms were rated with the Brief Psychiatric Ra ting Scale (BPRS) and Scales for the Assessment of Positive and Negative Sy mptoms (SAPS and SANS), and while subjective disturbances were assessed by the Frankfurter Beschwerde Fragebogen (FBF, also called the Complaint Quest ionnaire). Correlation analysis showed that P300 amplitude was inversely co rrelated with subjective experiences of cognitive deficit, especially in th e area of automatic skills and overstimulation. No relationship emerged bet ween BPRS, SANS, and SAPS scores and P300 alterations. The results suggest that subjective cognitive disturbances, more than objective symptoms, are r elated to P300 alterations in schizophrenia, and that the FBF questionnaire appropriately covers the domain of schizophrenic cognitive disorders. Copy right (C) 1999 by W.B. Saunders Company.