Gene structure and chromosome mapping of the human small-conductance calcium-activated potassium channel SK1 gene (KCNN1)

Authors
Litt, M LaMorticella, D Bond, CT Adelman, JP
Citation
M. Litt et al., Gene structure and chromosome mapping of the human small-conductance calcium-activated potassium channel SK1 gene (KCNN1), CYTOG C GEN, 86(1), 1999, pp. 70-73
Citations number
10
Categorie Soggetti
Molecular Biology & Genetics
Journal title
CYTOGENETICS AND CELL GENETICS
ISSN journal
03010171 → ACNP
Volume
86
Issue
1
Year of publication
1999
Pages
70 - 73
Database
ISI
SICI code
0301-0171(1999)86:1<70:GSACMO>2.0.ZU;2-4
Abstract
Small-conductance, calcium-activated potassium channels contribute to the a fterhyperpolarization in central neurons and other cell types. Because thes e channels regulate neuronal excitability, defects in their genes could cau se excitability disorders. The human cDNA encoding one such channel, SK1 (K CNN1), was recently cloned. Here we describe the gene structure of KCNN1 an d its localization by radiation hybrid mapping to chromosome 19p13.1.