Bi. Gorenstein et al., Mechanisms of metabolic action of antitumor low-molecular-weight peptides - L-glutamine derivatives, DAN BELARUS, 43(2), 1999, pp. 44-47
The mechanisms of metabolic action of Deglutame (DG), anticancer low-molecu
lar-weight: L-glutamine(Gln)-derived peptide, on rat tumors W-256, SM-1, SM
-45 and PC-1 has been investigated. It was demonstrated that action of DG w
as realized by "antiglutamine" mechanism only after its peroral administrat
ion. The metabolic effects of the preparation depend on actual concentratio
ns of Gln and amino acids competing with the latter for common transport sy
stem.