Immunomodulation of various autoimmune diseases by intravenous immunoglobulin

Authors
Sherer, Y Levy, Y Fabrizzi, F Shoenfeld, Y
Citation
Y. Sherer et al., Immunomodulation of various autoimmune diseases by intravenous immunoglobulin, DRUGS TODAY, 35(7), 1999, pp. 513-518
Citations number
46
Categorie Soggetti
Pharmacology
Journal title
DRUGS OF TODAY
ISSN journal
00257656 → ACNP
Volume
35
Issue
7
Year of publication
1999
Pages
513 - 518
Database
ISI
SICI code
0025-7656(199907)35:7<513:IOVADB>2.0.ZU;2-J
Abstract
Intravenous immunoglobulin (IVIg) is currently an accepted treatment for so me autoimmune diseases and it has recently been used empirically in various other autoimmune conditions. This review discusses the role of IVIg in aut oimmunity, mainly in systemic lupus erythematosus and systemic vasculitis. Clinical experience with IVIg, as well as its mechanisms of action with spe cial emphasis on modulation of the idiotypic network, are also presented. ( C) 1999 Prous Science. All rights reserved.