Autoimmune hypoglycemia is a rare but fascinating syndrome of hypoglycemia
caused by the interaction of endogenous antibodies with insulin or the insu
lin receptor. Awareness of autoimmune hypoglycemia is important because the
syndrome may produce severe neuroglycopenic symptoms and may be confused w
ith the presence of an insulinoma. A correct diagnosis is important to avoi
d unnecessary surgical intervention in patients who are best treated with c
onservative support, watchful waiting, or in some cases, immunosuppressive
therapy.