Effect of cromolyn pre-treatment on capsaicin-induced rhinitis in rats

The effect of cromolyn sodium local pre-treatment on capsaicin-induced rhin itis in rats was studied by analyzing tissue changes due to edema, inflamma tory cell infiltration and IgA upregulation. Nasal mucosa samples were stai ned with hematoxylin-eosin and examined immunohistochemically with monoclon al IEA antibodies. Changes were analyzed at 6, 12 and 72 h after capsaicin treatment and were scored semiquantitatively. Results showed that local cro molyn pre-treatment modified all parameters observed in the nasal mucosa fo llowing capsaicin-induced rhinitis in the rats.