The concepts and techniques involved in the origins of psychosurgery d
uring the late nineteenth century are analysed, particularly in the wo
rk of Claye Shaw and Gottlieb Burckhardt. It is shown that their views
and therapeutic behaviour were guided by scientific, ethical and soci
al warrants not dissimilar those of today. The debate that followed th
eir work can thus be considered as a trial run to that elicited by the
work of Moniz. This paper focuses on the work of Shaw, Cripps, Tuke a
nd Duncan for, until now, it has not featured in any history of psycho
surgery. From the point of view of the history of science, their work
is important, for it relates to the debate on brain localization, neur
onal circuits and the neurobiological representation of mental illness
that took place at the dawn of the twentieth century. Nothing is said
on the history of psychosurgery subsequent to the work of Moniz.