Gaucher's disease is frequentely associated with immunologic abnormalities,
eg. hypergammaglobulinemia, polyclonal gammopathy and benign monoclonal ga
mmopathy. A patient with Gaucher's disease and a selective accumulation of
IgM k in Gaucher's cells without serum monoclonal gammopathies is described
. The selective accumulation is detected by immunohistochemistry analysis p
erformed on cryostat bone marrow biopsies.