Possible inhibitory mechanism of FK506 (tacrolimus hydrate) ointment for atopic dermatitis based on animal models

Authors
Sengoku, T Morita, K Sakuma, S Motoyama, Y Goto, T
Citation
T. Sengoku et al., Possible inhibitory mechanism of FK506 (tacrolimus hydrate) ointment for atopic dermatitis based on animal models, EUR J PHARM, 379(2-3), 1999, pp. 183-189
Citations number
33
Categorie Soggetti
Pharmacology & Toxicology
Journal title
EUROPEAN JOURNAL OF PHARMACOLOGY
ISSN journal
00142999 → ACNP
Volume
379
Issue
2-3
Year of publication
1999
Pages
183 - 189
Database
ISI
SICI code
0014-2999(19990827)379:2-3<183:PIMOF(>2.0.ZU;2-B
Abstract
The effects of FK506 (tacrolimus hydrate) ointment on cutaneous allergic re actions in mice and rats were investigated. FK506 ointment showed significa nt suppressive effects on delayed allergic reactions in both species, and e specially in rats, its inhibitory action was much stronger than that of alc lometasone dipropionate, a so-called medium class steroid ointment. On the other hand, FK506 ointment did not inhibit the immediate allergic reaction in rats. FK506 ointment suppressed the delayed allergic reactions in locall y passively sensitized mice to the same degree as that in actively sensitiz ed mice. Accordingly, it is speculated that FK506 ointment inhibits the act ivation of sensitized T lymphocytes (Th1 cells) already accumulated in the dermis. (C) 1999 Elsevier Science B.V. All rights reserved.