A. Plettenberg et al., INCREASED RISK FOR OPPORTUNISTIC INFECTIONS DURING CHEMOTHERAPY IN HIV-INFECTED PATIENTS WITH KAPOSIS-SARCOMA, Dermatology, 194(3), 1997, pp. 234-237
Background: Kaposi's sarcoma (KS) is the most frequent neoplasm in pat
ients with AIDS, responsible for death in about 20-30% of the affected
patients. Objective: To determine the frequency of opportunistic infe
ctions (OI) and change of CD4+ cell counts in patients with KS treated
with chemotherapy compared to a group of matched-pair patients withou
t chemotherapy. Methods: In a prospective study, the clinical courses
of 35 HIV-infected patients with KS treated with chemotherapy were com
pared with 35 matched-pair patients without chemotherapy. Results: Dur
ing the observation period of 6 months, 11 OI occurred in 10 patients
of the chemotherapy group and 5 OI in 5 patients of the control group.
With respect to the changes of CD4+ cell counts, no significant diffe
rences could be observed. Conclusion: The risk for OI in HIV-infected
patients with KS is increased while receiving chemotherapy. This shoul
d be reflected upon when chemotherapy is taken into consideration.