LINEAR IGA BULLOUS DERMATOSIS AFTER CONTACT WITH SODIUM-HYPOCHLORITE

The onset of linear IgA bullous dermatosis (LABD) is generally spontan eous, but a number of cases of LABD have been reported either followin g drug exposure or in association with malignancies. We describe a pat ient who developed a vesicular eruption shortly after an irritant derm atitis caused by the contact with a detergent containing sodium hypoch lorite. Direct immunofluorescence revealed Linear deposits of IgA and C3 in the epidermal basement membrane. The patient's serum contained I EA that immunoblotted a 180-kD polypeptide in extracts of human kerati nocytes. The patient responded promptly to therapy with dapsone. We su ggest a possible pathogenetic relationship between the chemical dermat itis and LABD in this patient.