IMMUNOHISTOCHEMISTRY WITH MONOCLONAL-ANTIBODY AGAINST CANDIDA-ALBICANS MANNAN ANTIGEN DEMONSTRATES CUTANEOUS CANDIDA GRANULOMAS AS EVIDENCEOF CANDIDA SEPSIS IN AN IMMUNOSUPPRESSED HOST

We report the occurrence of invasive Candida albicans infection with d isseminated cutaneous Candida granulomas in a patient with aplastic an aemia after viral hepatitis. Fungal elements in a skin biopsy specimen were detected by PAS stain and identified as Candida sp. by immunohis tochemistry directed against the C. albicans mannan surface antigen. B ased on rapid diagnosis of Candida granuloma and by Candida-positive c ultures of blood and swabs, systemic treatment with liposomal amphoter icin B led to survival of the patient.