POSSIBLE ASSOCIATION OF INFERTILITY WITH SPERM-SPECIFIC ABNORMALITY OF CD46

Authors
KITAMURA M MATSUMIYA K YAMANAKA M TAKAHARA S HARA T MATSUMOTO M NAMIKI M OKUYAMA A SEYA T
Citation
M. Kitamura et al., POSSIBLE ASSOCIATION OF INFERTILITY WITH SPERM-SPECIFIC ABNORMALITY OF CD46, Journal of reproductive immunology, 33(1), 1997, pp. 83-88
Citations number
9
Categorie Soggetti
Reproductive Biology",Immunology
Journal title
Journal of reproductive immunology → ACNP
ISSN journal
01650378
Volume
33
Issue
1
Year of publication
1997
Pages
83 - 88
Database
ISI
SICI code
0165-0378(1997)33:1<83:PAOIWS>2.0.ZU;2-W
Abstract
Three infertile patients fulfilling normal or subnormal criteria on ro utine semen analysis showed abnormal sperm CD46 (membrane cofactor pro tein of complement) by SDS-PAGE/immunoblotting analysis using a panel of monoclonal antibodies. The sperm CD46 isoform has been reported to be associated with sperm-egg interaction. These three patients express ed normal CD46 isoforms on their lymphocytes and granulocytes. Sperm-s pecific abnormalities in these proteins thus parallel male infertility , suggesting a new category of infertility, probably due to aberration s in the molecules related to sperm-egg interaction. (C) 1997 Elsevier Science Ireland Ltd.