Metal complexation and DNA cleavage activities of N-substituted hydroxamicacids

Authors
Ghosh, KK Tamrakar, P Jadhav, VR
Citation
Kk. Ghosh et al., Metal complexation and DNA cleavage activities of N-substituted hydroxamicacids, I J CHEM A, 38(7), 1999, pp. 712-715
Citations number
23
Categorie Soggetti
Chemistry
Journal title
INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY
ISSN journal
03764710 → ACNP
Volume
38
Issue
7
Year of publication
1999
Pages
712 - 715
Database
ISI
SICI code
0376-4710(199907)38:7<712:MCADCA>2.0.ZU;2-Z
Abstract
Hydroxamic acid, RCON(R')OH, is a bidentate oxygen ligand possessing affini ty for a variety of metal ions. The Cu(II) complexes of three N-substituted hydroxamic acids [R=C6H5; R'=C6H5, 4-CH3 - C6H4 and R'= C6H5.CH2 ] have be en synthesized and characterized. Their DNA cleavage activities have been i nvestigated using plasmid DNA. An oxidative mechanism for DNA cleavage by h ydroxy radicals via abstraction of a H atom from sugar unit has been propos ed.