Microbiology of infected pustular psoriasis lesions

Background Bacterial infections can occur in lesions of pustular psoriasis (PP). The objective of this study was to establish the aerobic and anaerobi c microbiology of secondarily infected PP. Methods A retrospective 10-year review was carried out of clinical and micr obiology laboratory records from patients with secondarily infected PP lesi ons, whose specimens of infected sites were processed for the presence of a erobic and anaerobic bacteria. Results Bacterial growth was noted in 23 specimens. Aerobic or facultative anaerobic bacteria only were present in 12 patients (52%), anaerobic bacter ia only in four (17%), and mixed anaerobic-aerobic flora was present in sev en (30%). Thirty-six isolates were recovered (1.6 per specimen), 23 aerobic or facultative bacteria and 13 strict anaerobes. The predominant aerobic a nd facultative bacteria were Staphylococcus aureus (15 isolates), Group D E nterococcus (two isolates), and Escherichia coli (two isolates). The predom inant anaerobes were Peptostreptococcus spp. (six isolates) and Bacteroides fragilis group, Propionibacterium acnes, and pigmented Prevotella spp, in two each. Single bacterial isolates were recovered in 14 patients (61%), 11 of which were S. aureus. Nineteen of the organisms isolated from 18 patien ts (78%) produced the enzyme betalactamase. S. aureus was isolated from all body sites. Organisms that resided in the mucous membranes close to the le sions predominated in these infections. Enteric Gram-negative rods and Bact eroides fragilis group predominated in lesions on the legs and buttocks. Gr oup A beta-hemolytic streptococci, pigmented Prevotella, and Fusobacterium spp. were most frequently recovered in lesions of the hand. Conclusions The polymicrobial etiology of secondarily infected PP lesions a nd the association of bacterial flora with the anatomic site of the lesions were demonstrated.