Indomethacin is used commonly for the prevention of postoperatively heterot
opic ossification. There have been 3 reports in the pharmacologic literatur
e of indomethacin-induced psychosis. We describe a case of indomethacin-ind
uced psychosis in a patient in whom indomethacin was used for the preventio
n of postoperative heterotopic ossification after bilateral uncemented tota
l hip replacements.