Role of CCAA nucleotide repeats in regulation of hemoglobin and hemoglobin-haptoglobin binding protein genes of Haemophilus influenzae

Authors
Ren, Z Jin, HF Whitby, PW Morton, DJ Stull, TL
Citation
Z. Ren et al., Role of CCAA nucleotide repeats in regulation of hemoglobin and hemoglobin-haptoglobin binding protein genes of Haemophilus influenzae, J BACT, 181(18), 1999, pp. 5865-5870
Citations number
18
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF BACTERIOLOGY
ISSN journal
00219193 → ACNP
Volume
181
Issue
18
Year of publication
1999
Pages
5865 - 5870
Database
ISI
SICI code
0021-9193(199909)181:18<5865:ROCNRI>2.0.ZU;2-K
Abstract
Haemophilus influenzae utilizes hemoglobin and hemoglobin-haptoglobin as he me sources. The H. influenzae hemoglobin- and hemoglobin-haptoglobin bindin g protein genes, hgpA, hgpB, and hgpC, contain lengths of tetrameric CCAA r epeats. Using an hgpA-lacZ translational gene fusion, we demonstrate phase- variable expression of lacZ associated with alteration in the length of the CCAA repeat region.