DNASP VERSION-2.0 - A NOVEL SOFTWARE PACKAGE FOR EXTENSIVE MOLECULAR POPULATION-GENETICS ANALYSIS

Motivation: Several methods in molecular population genetics have rece ntly been described to estimate the amount and pattern of the DNA poly morphism in natural populations, and also to test the neutral theory o f molecular evolution. These methods are essential for understanding t he molecular evolutionary process. However, a comprehensive computer p rogram for the analysis is nor currently available. Results: Here we p resent DnaSP (DNA Sequence Polymorphism) version 2.0, a software packa ge for Windows that performs extensive population genetics analyses on DNA sequence data. DnaSP estimates several measures of DNA sequence v ariation within and between populations, linkage disequilibrium, recom bination, gene flow and gene conversion (a new algorithm to detect gen e conversion tracts has been included). DnaSP can also carry out sever al tests of neutrality: those of Fu and Li; Hudson, Kreitman and Aguad e; and Tajima. The results of the analyses are displayed in tabular an d graphic form. Availability: For academic uses, DnaSP is available vi a anonymous ftp:ftp.ebi.ac.uk in the directory /pub/software/ dos.