Neurogenic inflammation and muscle pain

Neurogenic inflammation is due to at least two mechanisms which interact: 1 . the activation of the sympathetic nervous system; 2, the antidromic relea se of neuropeptides from sensory afferent end organs. These mechanisms indu ce the modification of peripheral microenvironment characteristic of inflam mation. The pathophysiological and clinical significance of neurogenic infl ammation in muscle pain, both in visceral and somatic structures, are exami ned.