Regulation of mesangial cell proliferation

Regardless of the source of injury, an imbalance in the control of mesangia l cell proliferation appears to play a direct role in the degree of progres sive renal injury and glomerulosclerosis. Some of the regulatory mechanisms include specific soluble or non-soluble extracellular factors and a comple x array of receptor-mediated signals that control the progression of the ce ll cycle or cell death. Understanding these regulatory processes could lead to novel therapeutic strategies to alleviate or arrest proliferative glome rular disease.