Cell cycle regulatory proteins in glomerular disease

Evidence is accumulating that directly responsible for the rate of progress ion of glomerular disease are specific positive (cyclins and cyclin-depende nt kinases) and negative (cyclin-kinase inhibitors) cell cycle regulatory p roteins. The challenge for nephrologists is to determine which ones are exp ressed in renal disease and their precise role in glomerular cell prolifera tion, hypertrophy and differentiation. Ultimately the goal is to find ever more appropriate therapeutic strategies to arrest or prevent progressive re nal disease.