Cyclosporine A-induced cell cycle arrest and cell death in renal epithelial cells

Authors
Lally, C Healy, E Ryan, MP
Citation
C. Lally et al., Cyclosporine A-induced cell cycle arrest and cell death in renal epithelial cells, KIDNEY INT, 56(4), 1999, pp. 1254-1257
Citations number
37
Categorie Soggetti
Urology & Nephrology","da verificare
Journal title
KIDNEY INTERNATIONAL
ISSN journal
00852538 → ACNP
Volume
56
Issue
4
Year of publication
1999
Pages
1254 - 1257
Database
ISI
SICI code
0085-2538(199910)56:4<1254:CACCAA>2.0.ZU;2-9
Abstract
We studied the effects of cyclosporine A (CsA) on the proliferation of LLC- PK1 proximal tubule epithelial cells. DNA damage was found to be an early e vent in CsA nephrotoxicity and could be a sensitive indicator of CsA injury in renal epithelial cells. Cell cycle arrest induced by CsA was coincident with elevated p53 levels. It is possible that trans-activating p21 may med iate the halting of the cell cycle through the CsA-induced accumulation of p53.