Molecular controls of radiation-induced apoptosis in the neonatal rat kidney

Authors
Gobe, G Schoch, E Leighton, J
Citation
G. Gobe et al., Molecular controls of radiation-induced apoptosis in the neonatal rat kidney, KIDNEY INT, 56(4), 1999, pp. 1305-1309
Citations number
11
Categorie Soggetti
Urology & Nephrology","da verificare
Journal title
KIDNEY INTERNATIONAL
ISSN journal
00852538 → ACNP
Volume
56
Issue
4
Year of publication
1999
Pages
1305 - 1309
Database
ISI
SICI code
0085-2538(199910)56:4<1305:MCORAI>2.0.ZU;2-#
Abstract
The incidence of cell death due to radiation was examined in a neonatal in vivo model. Differences in the induction of apoptosis, amount of cell proli feration, S-phase cell death, Bcl-2 and p-53 expression could best be expla ined by the differences in the zonal state of differentiation and developme nt. The present in vivo model may thus be useful in testing radiation thera pies for renal cancer.