Thrombocytosis with sideroblastic erythropoiesis: A mixed myeloproliferative myelodysplastic syndrome

Some patients with haematological neoplasms have features which overlap bet ween a myelodysplastic syndrome and a myeloproliferative disorder. Two such patients are reported, both having sideroblastic erythropoiesis and thromb ocytosis and one sequentially developing features of atypical chronic myelo id leukaemia, idiopathic myelofibrosis and acute megakaryoblastic leukaemia . The prevalence of thrombocytosis among cases of refractory anaemia with r ing sideroblasts may be as high as 15-20% and has implications for choice o f therapy.