Spin-echo planar spectroscopic imaging for fast lipid characterization in bone marrow

Lipid characterization of bone marrow in vivo with proton magnetic resonanc e spectroscopy was performed using Spin-Echo Planar Spectroscopic Imaging s equences. The methods are shown capable of rapidly generating two-dimension al chemical shift imaging data sets suitable for measuring lipid indices th at reflect unsaturation levels among triglycerides, as demonstrated in oil phantoms and bone marrow from a healthy volunteer. The volume coverage, spa tial resolution, acquisition speed; and spectral characteristics of Spin-Ec ho Planar Spectroscopic Imaging should make it attractive for clinical stud ies of diseases affecting normal lipid chemical composition. (C) 1999 Elsev ier Science Inc.