No association of paraoxonase gene polymorphism with atherosclerosis or Alzheimer's disease

Authors
Sodeyama, N Yamada, M Itoh, Y Suematsu, N Matsushita, M Otomo, E Mizusawa, H
Citation
N. Sodeyama et al., No association of paraoxonase gene polymorphism with atherosclerosis or Alzheimer's disease, NEUROLOGY, 53(5), 1999, pp. 1146-1148
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
53
Issue
5
Year of publication
1999
Pages
1146 - 1148
Database
ISI
SICI code
0028-3878(19990922)53:5<1146:NAOPGP>2.0.ZU;2-2
Abstract
Both AD and paraoxonase (PON) have been reported to be related to lipids an d atherosclerosis, suggesting that the PON gene (PON) is a possible genetic risk factor for AD. We found no association of PON polymorphism with sever ity of atherosclerosis, densities of AD-type, neuropathologic change, or de velopment of AD in 47 AD and 90 nondemented patients. Our study suggests th at PON polymorphism does not play a. causal role in the development of athe rosclerosis or AD.