Myocardial uptake of technetium-99m-furifosmin (Q12) versus technetium-99m-sestamibi (MIBI)

Aim: This study was performed to compare the myocardial uptake of Tc-99m-fu rifosmin (Q12) versus Tc-99m-sestamibi (MIBI) in correlation to the whole-b ody uptake under resting conditions. [Methods: 21 patients with coronary ar tery disease and no rest ischemia were examined. A whole-body scan was perf ormed 60 min, p.i, under resting conditions. A quantification of the uptake (whole-body, hear? and right lung) was done by ROI technique. Results: The heart-to-lung ratio of Q12 (1.56 +/- 0.191) was significantly lower as com pared to MIBI 11.94 +/- 0.197; p <0.01). In contrast, the heart-to-whole-bo dy ratios (Q12 versus MIBI: 0.027 +/- 0.012 versus 0.026 +/- 0.004; p <0.76 ) did not differ. The lung-to-whole-body ratio (Q12 Versus MIBI: 0.018 +/- 0.009 versus 0.013 +/- 0.002; p <0.17) were different, but did not reach si gnificance. Conclusion: These data show that under resting conditions the t otal myocardial uptake of Q12 does not differ significantly from that of MI BI. However, the pulmonary uptake of Q12 is slightly higher, resulting in a significant lower heart-to-lung ratio. These findings imply a lower image quality of Q12 compared to MIBI.