Effects of (1DMe)NPYF, a synthetic neuropeptide FF analogue, in different pain models

The antinociceptive effects of intrathecal (IT) (1DMe)NPYF were studied in adult Sprague-Dawley rats. (1DMe)NPYF produced dose-dependent antinocicepti on that was reduced by subcutaneous injection of naloxone. (1DMe)NPYF (0.5 nmol) also potentiated the antinociceptive effects of intrathecal morphine 7.8 nmol, This suggests that the antinociceptive effects of (1DMe)NPYF are partially mediated by opioid receptor activation. In carrageenan inflammati on, 5-10 nmol of (1DMe)NPYF was effective against both thermal hyperalgesia and mechanical allodynia. In the neuropathic pain model, the lowest dose t ested (0.5 nmol) showed antiallodynic effects against cold allodynia. The r esults suggest a potential role for (1DMe)NPYF in the treatment of pain inc luding neuropathic pain. (C) 1999 Elsevier Science Inc. All rights reserved .