Endothelin enhances adenosine and isoprenaline elevated cyclic AMP levels in rat cerebellar slices

In this study, we present evidence showing that endothelin (ET) potentiates the responses to adenosine, to 5'-N-ethylcarboxamidoad, a nonhydrolyzable adenosine agonist, and to isoprenaline. These responses seem to occur throu gh ET-B receptors, as all three endothelin isopeptides have the same potenc y, sarafotoxin 6c has the same effect as ET-1, BQ-123, an ET-A receptor ant agonist has no effect, and BQ-788, an ET-B receptor antagonist that totally suppresses the responses analyzed. (C) 1999 Elsevier Science Inc. All righ ts reserved.