Guaianolides from Centaurea nicolai: antifungal activity

A new guaianolide, 3-deacetyl-9-O-acetylsalograviolide A, along with four k nown closely related lactones, salograviolide A, 9-O-acetylsalograviolide A , kandavanolide and salograviolide B were detected in the aerial parts of t he flowering plant Centaurea nicolai. Antifungal tests performed on salogra violide A and its 9-O-acetyl and 3-O-deacetyl-9-O-acetyl derivatives reveal ed inhibitory activity against Aspergillus niger, A. ochraceus, Penticilliu m ochrochloron,Cladosporium cladosporodies, Fusharium tricinctum and Phomop sis helianthi. Neither of them was active against Trichoderma viride. (C) 1 999 Elsevier Science Ltd. All rights reserved.