Empirical strategy: Antibiotic therapy of upper and lower respiratory tract
infections is based on an empirical strategy. However, arguments favoring
the probability of a given bacteria may be lacking and, since resistance of
Streptococcus pneumoniae and Haemophilus influenzae against conventional a
ntibiotics is becoming increasingly frequent, therapeutic strategies must b
e revisited.
Sinusitis: H. influenzae and S. pneumoniae are the most frequent causal age
nts in acute maxillary sinusitis. For chronic sinusitis, beta-lactamase pro
ducing anaerobic bacteria, S. aureus and peni-resistant pneumococci and H.
influenzae must also be considered.
Acute exacerbations of chronic bronchitis: The main causal agents are H. in
fluenzae and S. pneumoniae, followed by M, catarrhalis, S. aureus, enteroba
cteriaceae, and beta-hemolytic streptococci.
Community acquired pneumonia: There are a wide range of pathogens, half of
which are identified in different studies.
Resistances: For pneumococci, penicillin resistance is currently evidenced
in 48% of the strains. For H. influenzae, 30% of the strains are ampicillin
resistant.