Cytokines in heart failure: Pathogenetic mechanisms and potential treatment

Authors
Dibbs, Z Kurrelmeyer, K Kalra, D Seta, Y Wang, F Bozkurt, B Baumgarten, G Sivasubramanian, N Mann, DL
Citation
Z. Dibbs et al., Cytokines in heart failure: Pathogenetic mechanisms and potential treatment, P ASS AM PH, 111(5), 1999, pp. 423-428
Citations number
54
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
PROCEEDINGS OF THE ASSOCIATION OF AMERICAN PHYSICIANS
ISSN journal
1081650X → ACNP
Volume
111
Issue
5
Year of publication
1999
Pages
423 - 428
Database
ISI
SICI code
1081-650X(199909/10)111:5<423:CIHFPM>2.0.ZU;2-Y
Abstract
Recent studies have shown that patients with heart failure overexpress a cl ass of biologically active molecules, generically referred to as pro-inflam matory cytokines. This article will review recent clinical and experimental material that suggests that pro-inflammatory cytokines such as tumor necro sis factor-alpha (TNF-alpha), interleukin-1 (IL-1), and interleukin-6 (IL-6 ) may play a role in the pathogenesis of congestive heart failure. In addit ion, we will review recent studies that suggest that antagonizing cytokines may represent a novel target for heart failure therapy.