Coincident induction of long-term facilitation in Aplysia: Cooperativity between cell bodies and remote synapses

Induction of Long-term synaptic changes at one synapse can facilitate the i nduction of Long-term plasticity at another synapse. Evidence is presented here that if Aplysia sensory neuron somata and their remote motor neuron sy napses are simultaneously exposed to serotonin pulses insufficient to induc e Long-term facilitation (LTF) at either site along, processes activated at these sites interact to induce LTF. This coincident induction of LTF requi res that (i) the synaptic pulse occur within a brief temporal window of the somatic pulse, and (ii) Local protein synthesis occur immediately at the s ynapse, followed by delayed protein synthesis at the soma.