Interaction of organic derivatives of tin (IV) and lead (IV) with model lipid membranes

Here we present the results of a comparative study on the interactions betw een the trialkyl-, triphenyl derivatives of tin (TV) and lead (IV) and dial kyl-, diphenyltin (IV) derivatives on the planar bilayer lipid membranes (B LMs), widely applied as a model of cell membrane. The relative degree of de polarization of the lipid membrane potential caused by the influence of the above compounds was applied as a parameter to estimate their toxicity. The research has shown, that trialkyl derivatives of tin (IV) are considered a s the most active ones in relation to BLM from all alkyl tin and lead deriv atives that have been studied. Dialkyltin (TV) and trialkyllead (IV) deriva tives were found to be the least active. In phenyl derivatives group, the a ctivity sequence is as follow: triphenyllead > triphenyltin > diphenyltin. Depolarization activity of compounds investigated strongly depended on the lipophilicity of their reaction with water products. (C) 1999 Elsevier Scie nce B.V. AU rights reserved.