F. Messina et al., Chiral azole derivatives, 3. Synthesis of the enantiomers of the potent aromatase inhibitor 1-[2-benzofuranyl(4-chlorophenyl)methyl]-1H-imidazole, TETRAHEDR L, 40(40), 1999, pp. 7289-7292
Starting from (+)- and (-)-1-(4-chlorophenyl)-2-propynylamine, in turn obta
ined by CAL-mediated kinetic resolution of the corresponding racemate, a st
ereoselective synthesis of both enantiomers of the title compound has been
achieved. (C) 1999 Published by Elsevier Science Ltd, All rights reserved.